Ammonium Chloride → HCID 67015503, compound

Participants

Reaction Steps

To a solution of 4′-[3-(2-methyl-pyridin-4-yl)-3-oxo-1-o-tolyl-propyl]-biphenyl-4-carboxylic acid (50 mg) in THF (1 mL) was added TBTU (41 mg) and triethylamine (0.048 mL) and the resulting mixture was stirred at room temperature for 10 min. Beta-alanine ethyl ester hydrochloride (21.2 mg) was added and the reaction mixture was stirred at rt overnight. A saturated solution of NH4Cl and EtOAc were added, the phases were separated and the inorganic one was extracted with EtOAc (2×). The combined organic layers were washed with brine, dried over Na2SO4, filtered and concentrated in vacuo to yield the title compound (72 mg) as a light yellow oil, MS (ESI+): m/z=535.3 ([M+H]+).

Provenance & Evidence