L-Alanine, ethyl ester, hydrochloride (1:1) → HCID 67015586, compound

HRID 1617526Notes

Reaction equation

HRID 1617526 reaction equation
[CH3:1][C:2]1[CH:7]=[C:6]([C:8](=[O:33])[CH2:9][C@@H:10]([C:18]2[CH:23]=[CH:22][C:21]([C:24]3[CH:29]=[CH:28][C:27]([C:30](O)=[O:31])=[CH:26][CH:25]=3)=[CH:20][CH:19]=2)[C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][C:12]=2[CH3:17])[CH:5]=[CH:4][N:3]=1.Cl.[CH2:35]([O:37][C:38](=[O:42])[C@H:39]([CH3:41])[NH2:40])[CH3:36]>>[CH2:35]([O:37][C:38](=[O:42])[C@@H:39]([NH:40][C:30]([C:27]1[CH:26]=[CH:25][C:24]([C:21]2[CH:20]=[CH:19][C:18]([C@@H:10]([C:11]3[CH:16]=[CH:15][CH:14]=[CH:13][C:12]=3[CH3:17])[CH2:9][C:8]([C:6]3[CH:5]=[CH:4][N:3]=[C:2]([CH3:1])[CH:7]=3)=[O:33])=[CH:23][CH:22]=2)=[CH:29][CH:28]=1)=[O:31])[CH3:41])[CH3:36]

Participants

3

Reactant 2

HCID 2724356L-Alanine, ethyl ester, hydrochloride (1:1)HCID 66666221HCID 66666221, compound

Product 1

HCID 67015586HCID 67015586, compound

Procedure

In analogy to example 89, step 2, from 4′-[(S)-3-(2-methyl-pyridin-4-yl)-3-oxo-1-o-tolyl-propyl]-biphenyl-4-carboxylic acid and L-alanine ethyl ester hydrochloride was prepared the title compound as a light yellow oil, MS (ESI+): m/z=535.3 ([M+H]+).

Sources & evidence

ORD record
ord-0458bf4353da45a3bbe22e11f2e6c899
Source dataset
uspto-grants-2014_07
Patent number
US08765730B2

Reaction notes

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