Glycine methyl ester hydrochloride → HCID 67015502, compound

HRID 1617528Notes

Reaction equation

HRID 1617528 reaction equation
[CH3:1][C:2]1[CH:7]=[C:6]([C:8](=[O:33])[CH2:9][C@H:10]([C:18]2[CH:23]=[CH:22][C:21]([C:24]3[CH:29]=[CH:28][C:27]([C:30](O)=[O:31])=[CH:26][CH:25]=3)=[CH:20][CH:19]=2)[C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][C:12]=2[CH3:17])[CH:5]=[CH:4][N:3]=1.Cl.[CH3:35][O:36][C:37](=[O:40])[CH2:38][NH2:39]>>[CH3:35][O:36][C:37](=[O:40])[CH2:38][NH:39][C:30]([C:27]1[CH:26]=[CH:25][C:24]([C:21]2[CH:20]=[CH:19][C:18]([C@H:10]([C:11]3[CH:16]=[CH:15][CH:14]=[CH:13][C:12]=3[CH3:17])[CH2:9][C:8]([C:6]3[CH:5]=[CH:4][N:3]=[C:2]([CH3:1])[CH:7]=3)=[O:33])=[CH:23][CH:22]=2)=[CH:29][CH:28]=1)=[O:31]

Participants

3

Reactant 2

HCID 122755Glycine methyl ester hydrochlorideHCID 66666365HCID 66666365, compound

Product 1

HCID 67015502HCID 67015502, compound

Procedure

In analogy to example 89, step 2, from 4′-[(R)-3-(2-methyl-pyridin-4-yl)-3-oxo-1-o-tolyl-propyl]-biphenyl-4-carboxylic acid (example 95, step 1) and glycine methyl ester hydrochloride was prepared the title compound as light yellow foam, MS (ESI+): m/z=507.2282 ([M+H]+).

Sources & evidence

ORD record
ord-1d08f84c22d7436887d49ec8576d208c
Source dataset
uspto-grants-2014_07
Patent number
US08765730B2

Reaction notes

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