Hydroxyamine hydrochloride → HCID 136385669, compound

Participants

Reaction Steps

In analogy to example 74, step 7, from ({4′-[(R)-3-(2-methyl-pyridin-4-yl)-3-oxo-1-o-tolyl-propyl]-biphenyl-4-carbonyl}-amino)-acetic acid and hydroxylamine hydrochloride in the presence of NaHCO3 was prepared ({4′-[(R)-3-[hydroxyimino]-3-(2-methyl-pyridin-4-yl)-1-o-tolyl-propyl]-biphenyl-4-carbonyl}-amino)-acetic acid as a mixture of isomers which was separated by chiral HPLC (Reprosil-Chiral-NR, 70% n-heptane, 30% ethanol+0.5% formic acid) to give the title compound as a white solid, MS (ESI+): m/z=508.3 ([M+H]+).

Provenance & Evidence