HCID 367506, compound → HCID 66666214, compound

HRID 1617533Notes

Reaction equation

HRID 1617533 reaction equation
[CH2:1]([O:3][C:4](=[O:16])[C:5]([C:14]#[N:15])=[CH:6][C:7]1[CH:12]=[CH:11][CH:10]=[C:9]([Br:13])[CH:8]=1)[CH3:2].[C:17]1([CH3:25])[CH:22]=[CH:21][CH:20]=[CH:19][C:18]=1[Mg]Cl>>[CH2:1]([O:3][C:4](=[O:16])[CH:5]([C:14]#[N:15])[CH:6]([C:7]1[CH:12]=[CH:11][CH:10]=[C:9]([Br:13])[CH:8]=1)[C:18]1[CH:19]=[CH:20][CH:21]=[CH:22][C:17]=1[CH3:25])[CH3:2]

Participants

3

Reactant 2

HCID 367506HCID 367506, compoundHCID 178424304HCID 178424304, compound

Product 1

HCID 66666214HCID 66666214, compound

Procedure

In analogy to example 74, step 2, from 3-(3-bromo-phenyl)-2-cyano-acrylic acid ethyl ester and o-tolylmagnesium chloride was prepared the title compound as a colorless oil, MS (ESI−): m/z=370.04 (([M−H]−), 1Br).

Sources & evidence

ORD record
ord-02c00dc10f084ef8b16a0641b61fc804
Source dataset
uspto-grants-2014_07
Patent number
US08765730B2

Reaction notes

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