HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydroxyamine hydrochloride → 3-(4'-Methane sulfonyl-biphenyl-3-yl)-1-(2-methyl-pyridin-4-yl)-3-o-tolyl-propan-1-one oxime
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydroxyamine hydrochloride | HCID 443297 | — |
| Reactant | Sodium Bicarbonate | HCID 516892 | — |
| Reactant | 3-(4'-Methanesulfonyl-biphenyl-3-yl)-1-(2-methyl-pyridin-4-yl)-3-o-tolyl-propan-1-one | HCID 67015522 | — |
| Product | 3-(4'-Methane sulfonyl-biphenyl-3-yl)-1-(2-methyl-pyridin-4-yl)-3-o-tolyl-propan-1-one oxime | HCID 136347941 | — |
Reaction Steps
In analogy to example 74, step 7, 3-(4′-methanesulfonyl-biphenyl-3-yl)-1-(2-methyl-pyridin-4-yl)-3-o-tolyl-propan-1-one and hydroxylamine hydrochloride in the presence of NaHCO3 was prepared the title compound as a mixture of E and Z isomers (4.8:1) as a white foam, MS (ESI+): m/z=485.19 ([M+H]+).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08765730B2 |
| Source dataset | uspto-grants-2014_07 |
| ORD ID | ord-9f93cea4eda549c9a573455e65953fb0 |
| Source note | uspto-grants-2014_07 |