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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1617545Generated: October 30, 2026

Ethyl cyanoacetate → Cyano-{3-[3-(2-methyl-pyridin-4-yl)-3-oxo-1-o-tolyl-propyl]-phenyl}-acetic acid ethyl ester

https://huagongshe.com/reaction/1617545

Reaction equation

Participants

RoleNameHCIDCharge
ReactantEthyl cyanoacetateHCID 7764—
ReactantHCID 67015516HCID 67015516—
ProductCyano-{3-[3-(2-methyl-pyridin-4-yl)-3-oxo-1-o-tolyl-propyl]-phenyl}-acetic acid ethyl esterHCID 66666121—

Reaction Steps

In analogy to example 80, step 1, from 3-(3-bromo-phenyl)-1-(2-methyl-pyridin-4-yl)-3-o-tolyl-propan-1-one (example 98, step 5) and ethyl cyanoacetate was prepared the title compound as a light yellow oil, MS (ESI+): m/z=427.2 ([M+H]+).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08765730B2
Source datasetuspto-grants-2014_07
ORD IDord-182ce502e71343188b4d91d17e391a20
Source noteuspto-grants-2014_07