Propargyl alcohol → 3-[3-(3-Hydroxy-prop-1-ynyl)-phenyl]-1-(2-methyl-pyridin-4-yl)-3-o-tolyl-propan-1-one

HRID 1617546Notes

Reaction equation

HRID 1617546 reaction equation
Br[C:2]1[CH:3]=[C:4]([CH:8]([C:19]2[CH:24]=[CH:23][CH:22]=[CH:21][C:20]=2[CH3:25])[CH2:9][C:10]([C:12]2[CH:17]=[CH:16][N:15]=[C:14]([CH3:18])[CH:13]=2)=[O:11])[CH:5]=[CH:6][CH:7]=1.[CH2:26]([OH:29])[C:27]#[CH:28]>>[OH:29][CH2:26][C:27]#[C:28][C:2]1[CH:3]=[C:4]([CH:8]([C:19]2[CH:24]=[CH:23][CH:22]=[CH:21][C:20]=2[CH3:25])[CH2:9][C:10]([C:12]2[CH:17]=[CH:16][N:15]=[C:14]([CH3:18])[CH:13]=2)=[O:11])[CH:5]=[CH:6][CH:7]=1

Participants

3

Reactant 2

HCID 7859Propargyl alcoholHCID 67015516HCID 67015516, compound

Product 1

HCID 666689683-[3-(3-Hydroxy-prop-1-ynyl)-phenyl]-1-(2-methyl-pyridin-4-yl)-3-o-tolyl-propan-1-one

Procedure

In analogy to example 85, step 1, from 3-(3-bromo-phenyl)-1-(2-methyl-pyridin-4-yl)-3-o-tolyl-propan-1-one (example 98, step 5) and 2-propyn-1-ol was prepared the title compound as a white foam, MS (ESI+): m/z=370.18 ([M+H]+).

Sources & evidence

ORD record
ord-bf9a3332c68e43f59bf063877b0c6088
Source dataset
uspto-grants-2014_07
Patent number
US08765730B2

Reaction notes

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