Hydroxyamine hydrochloride → 3-[3-(3-Hydroxy-prop-1-ynyl)-phenyl]-1-(2-methyl-pyridin-4-yl)-3-o-tolyl-propan-1-one oxime

Participants

Role	Name	HCID	Charge
Reactant	Hydroxyamine hydrochloride	HCID 443297	—
Reactant	Sodium Bicarbonate	HCID 516892	—
Reactant	3-[3-(3-Hydroxy-prop-1-ynyl)-phenyl]-1-(2-methyl-pyridin-4-yl)-3-o-tolyl-propan-1-one	HCID 66668968	—
Product	3-[3-(3-Hydroxy-prop-1-ynyl)-phenyl]-1-(2-methyl-pyridin-4-yl)-3-o-tolyl-propan-1-one oxime	HCID 136360002	—

Reaction Steps

In analogy to example 74, step 7, from 3-[3-(3-hydroxy-prop-1-ynyl)-phenyl]-1-(2-methyl-pyridin-4-yl)-3-o-tolyl-propan-1-one and hydroxylamine hydrochloride in the presence of NaHCO3 was prepared the title compound as a mixture of E and Z isomers (3:1) as a white foam, MS (ESI+): m/z=385.1 ([M+H]+).

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US08765730B2
Source dataset	uspto-grants-2014_07
ORD ID	ord-634f2e4c753c46c8a6ac3a320f5854d5
Source note	uspto-grants-2014_07