反应详情

In analogy to example 89, step 2, from 3′-[3-(2-methyl-pyridin-4-yl)-3-oxo-1-o-tolyl-propyl]-biphenyl-3-carboxylic acid (example 102, step 1) and glycine methyl ester hydrochloride was prepared ({3′-[3-(2-methyl-pyridin-4-yl)-3-oxo-1-o-tolyl-propyl]-biphenyl-3-carbonyl}-amino)-acetic acid methyl ester as a white foam, which was directly subjected to the next step. In analogy to example 75, from ({3′-[3-(2-methyl-pyridin-4-yl)-3-oxo-1-o-tolyl-propyl]-biphenyl-3-carbonyl}-amino)-acetic acid methyl ester was prepared the title compound as a white foam, MS (ESI−): m/z=491.3 ([M−H]−).