Hydrochloric Acid → HCID 66668689, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of 3-(4-bromo-phenyl)-1-(2-methoxy-pyridin-4-yl)-3-o-tolyl-propan-1-one (example 109, step 1; 190 mg) in dioxane (9 mL) was added concentrated hydrochloric acid (1 mL) and the mixture was heated to 100° C. for 2 h. The solution was cooled to rt and added to a mixture of water and EtOAc. The inorganic phase was extracted with EtOAc and the combined organic phases were washed with brine, dried over Na2SO4, filtered and concentrated in vacuo to yield the crude title compound as a white foam, MS (ESI+): m/z=396.1 ([M+H]+, 1Br).

Provenance & Evidence