Water → HCID 66669052, compound

Participants

Reaction Steps

To a solution of 4-[3-(4-bromo-phenyl)-3-o-tolyl-propionyl]-1H-pyridin-2-one (150 mg) in DMA (1 mL) was added potassium carbonate (58 mg) and methyl iodide (0.06 mL). The mixture was stirred at rt for 6 h, water and TBME were added. The phases were separated and the inorganic phase was extracted with TBME and EtOAc. The combined organic phases were washed with brine, dried over Na2SO4, filtered and concentrated in vacuo. The crude product was purified by flash chromatography on silica gel (EtOAc/n-heptane 1:10 to EtOAc) to yield the title compound as a light yellow foam, MS (ESI+): m/z=410.2 ([M+H]+, 1Br).

Provenance & Evidence