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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1617559Generated: November 2, 2026

4-Fluoro-3-(methoxycarbonyl)benzeneboronic acid → 4-Fluoro-4'-[3-(2-methyl-pyridin-4-yl)-3-oxo-1-o-tolyl-propyl]-biphenyl-3-carboxylic acid methyl ester

https://huagongshe.com/reaction/1617559

Reaction equation

Participants

RoleNameHCIDCharge
Reactant4-Fluoro-3-(methoxycarbonyl)benzeneboronic acidHCID 23005332—
Reactant3-(4-Bromo-phenyl)-1-(2-methyl-pyridin-4-yl)-3-o-tolyl-propan-1-oneHCID 66668180—
Product4-Fluoro-4'-[3-(2-methyl-pyridin-4-yl)-3-oxo-1-o-tolyl-propyl]-biphenyl-3-carboxylic acid methyl esterHCID 66666773—

Reaction Steps

In analogy to example 74, step 6, from 3-(4-bromo-phenyl)-1-(2-methyl-pyridin-4-yl)-3-o-tolyl-propan-1-one and (4-fluoro-3-methoxycarbonylphenyl)boronic acid was prepared the title compound as a yellow oil, MS (ESI+): m/z=468.1977 ([M+H]+).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08765730B2
Source datasetuspto-grants-2014_07
ORD IDord-baf627fd26b44de3bc0738711376d696
Source noteuspto-grants-2014_07