5-Chloro-2-fluoro-4-iodopyridine → 3-(4-Bromo-phenyl)-1-(5-chloro-2-fluoro-pyridin-4-yl)-3-o-tolyl-propan-1-one

HRID 1617564Notes

Reaction equation

HRID 1617564 reaction equation
[Br:1][C:2]1[CH:7]=[CH:6][C:5]([CH:8]([C:16]2[CH:21]=[CH:20][CH:19]=[CH:18][C:17]=2[CH3:22])[CH2:9][C:10](N(OC)C)=[O:11])=[CH:4][CH:3]=1.[Cl:23][C:24]1[C:25](I)=[CH:26][C:27]([F:30])=[N:28][CH:29]=1>>[Br:1][C:2]1[CH:3]=[CH:4][C:5]([CH:8]([C:16]2[CH:21]=[CH:20][CH:19]=[CH:18][C:17]=2[CH3:22])[CH2:9][C:10]([C:25]2[C:24]([Cl:23])=[CH:29][N:28]=[C:27]([F:30])[CH:26]=2)=[O:11])=[CH:6][CH:7]=1

Participants

3

Reactant 2

HCID 218653365-Chloro-2-fluoro-4-iodopyridineHCID 866609493-(4-Bromo-phenyl)-N-methoxy-N-methyl-3-o-tolyl-propionamide

Product 1

HCID 670155263-(4-Bromo-phenyl)-1-(5-chloro-2-fluoro-pyridin-4-yl)-3-o-tolyl-propan-1-one

Procedure

In analogy to example 74, step 5, from 3-(4-bromo-phenyl)-N-methoxy-N-methyl-3-o-tolyl-propionamide (example 74, step 4) and 5-chloro-2-fluoro-4-iodopyridine (CAS RN: [659731-48-3]) was prepared the title compound as a light yellow oil, MS (ESI−): m/z=430.0014 ([M−H]−, 1Br).

Sources & evidence

ORD record
ord-4b271733bf804c428ee9e56bda8f35e5
Source dataset
uspto-grants-2014_07
Patent number
US08765730B2

Reaction notes

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