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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1617568Generated: November 1, 2026

3,5-Dibromopyridine → 3-(3-Bromo-phenyl)-1-(5-bromo-pyridin-3-yl)-3-o-tolyl-propan-1-one

https://huagongshe.com/reaction/1617568

Reaction equation

Participants

RoleNameHCIDCharge
Reactant3,5-DibromopyridineHCID 69369—
Reactant3-(3-Bromo-phenyl)-N-methoxy-N-methyl-3-o-tolyl-propionamideHCID 86660965—
ReactantHCID 178418365HCID 178418365—
Product3-(3-Bromo-phenyl)-1-(5-bromo-pyridin-3-yl)-3-o-tolyl-propan-1-oneHCID 67015568—

Reaction Steps

In analogy to example 74, step 5, from 3-(3-bromo-phenyl)-N-methoxy-N-methyl-3-o-tolyl-propionamide (example 98, step 4) and 3,5-dibromopyridine (CAS RN: [625-92-3]) using i-propylmagnesium bromide instead of n-butyllithium was prepared the title compound as a white solid, MS (ESI+): m/z=457.9738 ([M+H]+, 1Br).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08765730B2
Source datasetuspto-grants-2014_07
ORD IDord-356d100575674de3aac029f37180b4ad
Source noteuspto-grants-2014_07