HuagongsheHuagongshe Chemistry Print Report · For research reference only
3,5-Dibromopyridine → 3-(3-Bromo-phenyl)-1-(5-bromo-pyridin-3-yl)-3-o-tolyl-propan-1-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3,5-Dibromopyridine | HCID 69369 | — |
| Reactant | 3-(3-Bromo-phenyl)-N-methoxy-N-methyl-3-o-tolyl-propionamide | HCID 86660965 | — |
| Reactant | HCID 178418365 | HCID 178418365 | — |
| Product | 3-(3-Bromo-phenyl)-1-(5-bromo-pyridin-3-yl)-3-o-tolyl-propan-1-one | HCID 67015568 | — |
Reaction Steps
In analogy to example 74, step 5, from 3-(3-bromo-phenyl)-N-methoxy-N-methyl-3-o-tolyl-propionamide (example 98, step 4) and 3,5-dibromopyridine (CAS RN: [625-92-3]) using i-propylmagnesium bromide instead of n-butyllithium was prepared the title compound as a white solid, MS (ESI+): m/z=457.9738 ([M+H]+, 1Br).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08765730B2 |
| Source dataset | uspto-grants-2014_07 |
| ORD ID | ord-356d100575674de3aac029f37180b4ad |
| Source note | uspto-grants-2014_07 |