Methanamine, N-methoxy-, hydrochloride (1:1) → HCID 86660992, compound

HRID 1617584Notes

Reaction equation

HRID 1617584 reaction equation
[Br:1][C:2]1[CH:7]=[CH:6][C:5]([CH:8]([C:13]2[CH:18]=[CH:17][CH:16]=[CH:15][C:14]=2[C:19]([F:22])([F:21])[F:20])[CH2:9][C:10](O)=[O:11])=[CH:4][CH:3]=1.Cl.[CH3:24][NH:25][O:26][CH3:27]>>[Br:1][C:2]1[CH:3]=[CH:4][C:5]([CH:8]([C:13]2[CH:18]=[CH:17][CH:16]=[CH:15][C:14]=2[C:19]([F:20])([F:21])[F:22])[CH2:9][C:10]([N:25]([O:26][CH3:27])[CH3:24])=[O:11])=[CH:6][CH:7]=1

Participants

3

Reactant 2

HCID 81138Methanamine, N-methoxy-, hydrochloride (1:1)HCID 66666587HCID 66666587, compound

Product 1

HCID 86660992HCID 86660992, compound

Procedure

In analogy to example 74, step 4, from 3-(4-bromo-phenyl)-3-(2-trifluoromethyl-phenyl)-propionic acid and N,O-dimethylhydroxylamine hydrochloride was prepared the title compound as a brown viscous oil, MS (ESI+): m/z=416.2 ([M+H]+, 1Br).

Sources & evidence

ORD record
ord-7faa29267b9148cca78ec6d99e482923
Source dataset
uspto-grants-2014_07
Patent number
US08765730B2

Reaction notes

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