1-(Methylsulfonyl)piperazine → HCID 136166908, compound

HRID 1617590Notes

Reaction equation

HRID 1617590 reaction equation
Br[C:2]1[CH:7]=[CH:6][C:5]([CH:8]([C:19]2[CH:24]=[CH:23][CH:22]=[CH:21][C:20]=2[CH3:25])[CH2:9]/[C:10](/[C:13]2[CH:18]=[CH:17][N:16]=[CH:15][CH:14]=2)=[N:11]\[OH:12])=[CH:4][CH:3]=1.[CH3:26][S:27]([N:30]1[CH2:35][CH2:34][NH:33][CH2:32][CH2:31]1)(=[O:29])=[O:28]>>[CH3:26][S:27]([N:30]1[CH2:35][CH2:34][N:33]([C:2]2[CH:7]=[CH:6][C:5]([CH:8]([C:19]3[CH:24]=[CH:23][CH:22]=[CH:21][C:20]=3[CH3:25])[CH2:9]/[C:10](/[C:13]3[CH:18]=[CH:17][N:16]=[CH:15][CH:14]=3)=[N:11]\[OH:12])=[CH:4][CH:3]=2)[CH2:32][CH2:31]1)(=[O:29])=[O:28]

Participants

3

Reactant 2

HCID 7091611-(Methylsulfonyl)piperazineHCID 136166933HCID 136166933, compound

Product 1

HCID 136166908HCID 136166908, compound

Procedure

In analogy to example 39, from (E)-3-(4-bromo-phenyl)-1-pyridin-4-yl-3-o-tolyl-propan-1-one oxime (example 31) and 1-methanesulfonyl-piperazine (CAS RN: [55276-43-2]) was prepared the title compound as an off-white foam, MS (ESI+): m/z=479.2 ([M+H]+).

Sources & evidence

ORD record
ord-38d64d9ffb774b8799468d6fd20077ba
Source dataset
uspto-grants-2014_07
Patent number
US08765730B2

Reaction notes

Loading…