1-(Methylsulfonyl)piperazine → HCID 136166909, compound

HRID 1617591Notes

Reaction equation

Br[C:2]1[CH:7]=[CH:6][C:5]([CH:8]([C:20]2[CH:25]=[CH:24][CH:23]=[CH:22][C:21]=2[C:26]([F:29])([F:28])[F:27])[CH2:9]/[C:10](/[C:13]2[CH:18]=[CH:17][N:16]=[C:15]([CH3:19])[CH:14]=2)=[N:11]\[OH:12])=[CH:4][CH:3]=1.[CH3:30][S:31]([N:34]1[CH2:39][CH2:38][NH:37][CH2:36][CH2:35]1)(=[O:33])=[O:32]>>[CH3:30][S:31]([N:34]1[CH2:39][CH2:38][N:37]([C:2]2[CH:7]=[CH:6][C:5]([CH:8]([C:20]3[CH:25]=[CH:24][CH:23]=[CH:22][C:21]=3[C:26]([F:29])([F:28])[F:27])[CH2:9]/[C:10](/[C:13]3[CH:18]=[CH:17][N:16]=[C:15]([CH3:19])[CH:14]=3)=[N:11]\[OH:12])=[CH:4][CH:3]=2)[CH2:36][CH2:35]1)(=[O:33])=[O:32]

Participants

Reactant 2

HCID 7091611-(Methylsulfonyl)piperazine

HCID 136167025HCID 136167025, compound

Product 1

HCID 136166909HCID 136166909, compound

Procedure

In analogy to example 39, from (E)-3-(4-bromo-phenyl)-1-(2-methyl-pyridin-4-yl)-3-(2-trifluoromethyl-phenyl)-propan-1-one oxime (example 132) and 1-methanesulfonyl-piperazine (CAS RN: [55276-43-2]) was prepared the title compound as a yellow foam, MS (ESI+): m/z=547.3 ([M+H]+).

Sources & evidence

ORD record: ord-79aca4fe8a384fcf99e39deb1fb1032d
Source dataset: uspto-grants-2014_07
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08765730B2

Reaction notes

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