1-(Methylsulfonyl)piperazine → (NE)-N-[(3R)-3-(2-methylphenyl)-1-(2-methyl-4-pyridinyl)-3-[4-(4-methylsulfonylpiperazin-1-yl)phenyl]propylidene]hydroxylamine

HRID 1617602Notes

Reaction equation

HRID 1617602 reaction equation
Br[C:2]1[CH:7]=[CH:6][C:5]([C@H:8]([C:20]2[CH:25]=[CH:24][CH:23]=[CH:22][C:21]=2[CH3:26])[CH2:9]/[C:10](/[C:13]2[CH:18]=[CH:17][N:16]=[C:15]([CH3:19])[CH:14]=2)=[N:11]\[OH:12])=[CH:4][CH:3]=1.[CH3:27][S:28]([N:31]1[CH2:36][CH2:35][NH:34][CH2:33][CH2:32]1)(=[O:30])=[O:29]>>[CH3:19][C:15]1[CH:14]=[C:13](/[C:10](=[N:11]/[OH:12])/[CH2:9][C@H:8]([C:5]2[CH:4]=[CH:3][C:2]([N:34]3[CH2:35][CH2:36][N:31]([S:28]([CH3:27])(=[O:30])=[O:29])[CH2:32][CH2:33]3)=[CH:7][CH:6]=2)[C:20]2[CH:25]=[CH:24][CH:23]=[CH:22][C:21]=2[CH3:26])[CH:18]=[CH:17][N:16]=1

Participants

3

Reactant 2

HCID 7091611-(Methylsulfonyl)piperazineHCID 136166995(NE)-N-[(3R)-3-(4-bromophenyl)-3-(2-methylphenyl)-1-(2-methyl-4-pyridinyl)propylidene]hydroxylamine

Product 1

HCID 136166954(NE)-N-[(3R)-3-(2-methylphenyl)-1-(2-methyl-4-pyridinyl)-3-[4-(4-methylsulfonylpiperazin-1-yl)phenyl]propylidene]hydroxylamine

Procedure

In analogy to example 39, from (E,R)-3-(4-bromophenyl)-1-(2-methylpyridin-4-yl)-3-o-tolylpropan-1-one oxime (example 142, step 1) and 1-methanesulfonyl-piperazine (CAS RN: [55276-43-2]) was prepared the title compound as a yellow solid, MS (ESI+): m/z=493.3 ([M+H]+).

Sources & evidence

ORD record
ord-1f4af9030735410a8df4cf648df79c77
Source dataset
uspto-grants-2014_07
Patent number
US08765730B2

Reaction notes

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