反应详情

温度

100 °C

In analogy to example 74, step 6, (E)-3-(4-bromo-phenyl)-3-(4-chloro-2-fluoro-phenyl)-1-(2-methyl-pyridin-4-yl)-propan-1-one oxime (example 147, step 5) was reacted with 5-(ethoxycarbonyl)thiophen-3-ylboronic acid in the presence of dichloro(1,1′-bis(diphenylphosphino)ferrocene)palladium(II) dichloromethane adduct in a mixture of 1,4-dioxane, water and 2 M aqueous sodium carbonate solution under heating by microwave irradiation to 100° C. for 30 min providing the title compound as an off-white solid, MS (ESI+): m/z=523.2 [M+H]+.