Hydroxyamine hydrochloride → HCID 136167019, compound

Participants

Reaction Steps

In analogy to example 151, step 1, 7-chloro-4-iodoquinoline was reacted first with n-butyllithium and later with 3-(4-bromo-phenyl)-N-methoxy-N-methyl-3-o-tolyl-propionamide (example 74, step 4). The product of this reaction could not be obtained pure and was reacted in analogy to example 151, step 3, with hydroxylamine hydrochloride in the presence of NaHCO3 to give the title compound containing less than 10% of the corresponding Z isomer as a colorless solid, MS (ESI−): m/z=478.9 [M−H]−.

Provenance & Evidence