Water → HCID 66668631, compound

Participants

Reaction Steps

To a solution of 5-(3,3-diphenyl-propionyl)-1H-pyridin-2-one (60 mg, example 160, step 5) in N,N-dimethylacetamide (1 ml) were added powdered potassium carbonate (30 mg) and iodomethane (30 mg). The mixture was stirred at room temperature for 5.5 h. Water was added and the mixture was extracted with ethyl acetate. The organic phase was dried (MgSO4), filtered and concentrated to dryness. The product was purified by chromatography (SiO2, dichloromethane/methanol 1:0 to 85:15) to give the title compound (54 mg) as a colorless solid, MS (ESI+): m/z=318.2 [M+H]+.

Provenance & Evidence