HuagongsheHuagongshe Chemistry Print Report · For research reference only
5-Bromo-2-methoxypyridine → 3-(4-Bromo-phenyl)-1-(6-methoxy-pyridin-3-yl)-3-o-tolyl-propan-1-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 5-Bromo-2-methoxypyridine | HCID 2734895 | — |
| Reactant | 3-(4-Bromo-phenyl)-N-methoxy-N-methyl-3-o-tolyl-propionamide | HCID 86660949 | — |
| Reactant | Butyllithium | HCID 178418339 | — |
| Product | 3-(4-Bromo-phenyl)-1-(6-methoxy-pyridin-3-yl)-3-o-tolyl-propan-1-one | HCID 67015569 | — |
Reaction Steps
In analogy to example 151, step 1, 5-bromo-2-methoxypyridine was reacted first with n-butyllithium and later with 3-(4-bromo-phenyl)-N-methoxy-N-methyl-3-o-tolyl-propionamide (example 74, step 4) to give the title compound as a colorless oil, MS (ESI+): m/z=410.2 [M+H]+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08765730B2 |
| Source dataset | uspto-grants-2014_07 |
| ORD ID | ord-e8023d531e864f9c9706bfeca4dd5fb0 |
| Source note | uspto-grants-2014_07 |