HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → 5-[3-(4-bromo-2-fluoro-phenyl)-3-o-tolyl-propionyl]-1H-pyridin-2-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | 3-(4-Bromo-2-fluoro-phenyl)-1-(6-methoxy-pyridin-3-yl)-3-o-tolyl-propan-1-one | HCID 67015571 | — |
| Solvent | 1,4-Dioxane | HCID 31275 | — |
| Product | 5-[3-(4-bromo-2-fluoro-phenyl)-3-o-tolyl-propionyl]-1H-pyridin-2-one | HCID 66668898 | — |
Reaction Steps
In analogy to example 162, step 2, 3-(4-bromo-2-fluoro-phenyl)-1-(6-methoxy-pyridin-3-yl)-3-o-tolyl-propan-1-one was reacted with concentrated aqueous HCl in 1,4-dioxane to give the title compound as a colorless foam, MS (ESI+): m/z=414.1 [M+H]+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08765730B2 |
| Source dataset | uspto-grants-2014_07 |
| ORD ID | ord-514fa5f94e474a6e8dee06e701831333 |
| Source note | uspto-grants-2014_07 |