Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Hydroxyamine hydrochloride → 5-[(E)-C-[2-(4-bromo-2-fluorophenyl)-2-(2-methylphenyl)ethyl]-N-hydroxycarbonimidoyl]-1-methylpyridin-2-one
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Hydroxyamine hydrochloride | HCID 443297 | — |
| 반응물 | Sodium Bicarbonate | HCID 516892 | — |
| 반응물 | 5-[3-(4-Bromo-2-fluoro-phenyl)-3-o-tolyl-propionyl]-1-methyl-1H-pyridin-2-one | HCID 66669287 | — |
| 생성물 | 5-[(E)-C-[2-(4-bromo-2-fluorophenyl)-2-(2-methylphenyl)ethyl]-N-hydroxycarbonimidoyl]-1-methylpyridin-2-one | HCID 58043200 | — |
반응 단계
In analogy to example 151, step 3, 5-[3-(4-bromo-2-fluoro-phenyl)-3-o-tolyl-propionyl]-1-methyl-1H-pyridin-2-one was reacted with hydroxylamine hydrochloride in the presence of NaHCO3 to give the title compound as a colorless solid, MS (ESI+): m/z=443.1 [M+H]+.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08765730B2 |
| 출처 데이터셋 | uspto-grants-2014_07 |
| ORD ID | ord-0c7b6981c2174dd9bd09ed53daeb9135 |
| 출처 메모 | uspto-grants-2014_07 |