HuagongsheHuagongshe Chemistry Print Report · For research reference only
Benzotriazol-1-yloxy-tris(dimethylamino)phosphonium hexafluorophosphate → HCID 66668444, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Benzotriazol-1-yloxy-tris(dimethylamino)phosphonium hexafluorophosphate | HCID 151348 | — |
| Reactant | 3-Oxetanamine | HCID 9833923 | — |
| Reactant | HCID 66668801 | HCID 66668801 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | HCID 66668444 | HCID 66668444 | — |
Reaction Steps
In analogy to example 207, step 2, 4-(1-(2-chlorophenyl)-3-(1-methyl-6-oxo-1,6-dihydropyridin-3-yl)-3-oxopropyl)-2-fluorobenzoic acid (example 216, step 4) was coupled with oxetan-3-amine using BOP reagent in tetrahydrofuran to give the title compound as a colorless foam, MS (ESI+): m/z=469.2 [M+H]+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08765730B2 |
| Source dataset | uspto-grants-2014_07 |
| ORD ID | ord-1b20a4d157ce468a9c99b92c624cbefe |
| Source note | uspto-grants-2014_07 |