Water → HCID 67015552, compound

Participants

Reaction Steps

To a stirred solution of 5-[3-(2-fluoro-4-hydroxy-phenyl)-3-o-tolyl-propionyl]-1-methyl-1H-pyridin-2-one (71 mg) in N,N-dimethylacetamide (1.5 ml) were added ethylbromoacetate (36 mg) and cesium carbonate (69 mg). The mixture was stirred for 3.5 h at room temperature. Water was added and the mixture was extracted with diethyl ether. The organic phase was dried (MgSO4), filtered and concentrated to dryness. The product was purified by chromatography (SiO2, cyclohexane/ethyl acetate 1:0 to 0:1) to give the title compound (77 mg) as a light brown oil, MS (ESI+): m/z=452.2 [M+H]+.

Provenance & Evidence