HuagongsheHuagongshe Chemistry Print Report · For research reference only
5-Bromo-2-methoxypyridine → (R)-3-(4-Bromophenyl)-1-(6-methoxypyridin-3-yl)-3-o-tolylpropan-1-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 5-Bromo-2-methoxypyridine | HCID 2734895 | — |
| Reactant | (R)-3-(4-Bromophenyl)-N-methoxy-N-methyl-3-o-tolylpropanamide | HCID 71813344 | — |
| Reactant | Butyllithium | HCID 178418339 | — |
| Product | (R)-3-(4-Bromophenyl)-1-(6-methoxypyridin-3-yl)-3-o-tolylpropan-1-one | HCID 67015570 | — |
Reaction Steps
In analogy to example 151, step 1, 5-bromo-2-methoxypyridine was reacted first with n-butyllithium and later with (R)-3-(4-bromo-phenyl)-N-methoxy-N-methyl-3-o-tolyl-propionamide (example 142, step 1) to give the title compound as a colorless oil, MS (ESI+): m/z=410.1 [M+H]+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08765730B2 |
| Source dataset | uspto-grants-2014_07 |
| ORD ID | ord-b703aa2079ed4320ac39aa6f7c8d661e |
| Source note | uspto-grants-2014_07 |