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5-Bromo-2-methoxypyridine → (R)-3-(4-Bromophenyl)-1-(6-methoxypyridin-3-yl)-3-o-tolylpropan-1-one
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 5-Bromo-2-methoxypyridine | HCID 2734895 | — |
| 反応物 | (R)-3-(4-Bromophenyl)-N-methoxy-N-methyl-3-o-tolylpropanamide | HCID 71813344 | — |
| 反応物 | Butyllithium | HCID 178418339 | — |
| 生成物 | (R)-3-(4-Bromophenyl)-1-(6-methoxypyridin-3-yl)-3-o-tolylpropan-1-one | HCID 67015570 | — |
反応手順
In analogy to example 151, step 1, 5-bromo-2-methoxypyridine was reacted first with n-butyllithium and later with (R)-3-(4-bromo-phenyl)-N-methoxy-N-methyl-3-o-tolyl-propionamide (example 142, step 1) to give the title compound as a colorless oil, MS (ESI+): m/z=410.1 [M+H]+.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08765730B2 |
| 出典データセット | uspto-grants-2014_07 |
| ORD ID | ord-b703aa2079ed4320ac39aa6f7c8d661e |
| 出典メモ | uspto-grants-2014_07 |