5-Bromo-2-methoxypyridine → 3-(4-Bromophenyl)-3-(4-chloro-2-methylphenyl)-1-(6-methoxypyridin-3-yl)propan-1-one

Participants

Role	Name	HCID	Charge
Reactant	5-Bromo-2-methoxypyridine	HCID 2734895	—
Reactant	HCID 86660998	HCID 86660998	—
Reactant	Butyllithium	HCID 178418339	—
Product	3-(4-Bromophenyl)-3-(4-chloro-2-methylphenyl)-1-(6-methoxypyridin-3-yl)propan-1-one	HCID 67015717	—

Reaction Steps

In analogy to example 151, step 1, 5-bromo-2-methoxypyridine was reacted first with n-butyllithium and later with 3-(4-bromophenyl)-3-(4-chloro-2-methylphenyl)-N-methoxy-N-methylpropanamide (example 138, step 3) to give the title compound as a light yellow oil, MS (ESI+): m/z=446.03 [M+H]+.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US08765730B2
Source dataset	uspto-grants-2014_07
ORD ID	ord-2f7e5d0dafa946e6a3417de77c1fe300
Source note	uspto-grants-2014_07