Methanaminium, N-((dimethylamino)(3H-1,2,3-triazolo(4,5-b)pyridin-3-yloxy)methylene)-N-methyl-, hexafluorophosphate(1-) (1:1) → HCID 178426102, compound

HRID 1617749Notes

Reaction equation

HRID 1617749 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([CH:8]([C:21]2[CH:26]=[CH:25][C:24]([C:27]3[CH:32]=[CH:31][C:30]([C:33]([OH:35])=O)=[CH:29][CH:28]=3)=[CH:23][CH:22]=2)[CH2:9]/[C:10](=[N:19]\[OH:20])/[C:11]2[CH:16]=[CH:15][C:14](=[O:17])[N:13]([CH3:18])[CH:12]=2)=[C:4]([CH3:36])[CH:3]=1.[NH2:37][CH2:38][C:39]1[NH:43][N:42]=[N:41][N:40]=1.CN(C(ON1N=NC2C=CC=NC1=2)=[N+](C)C)C.F[P-](F)(F)(F)(F)F>>[NH:40]1[C:39]([CH2:38][NH:37][C:33]([C:30]2[CH:31]=[CH:32][C:27]([C:24]3[CH:25]=[CH:26][C:21]([CH:8]([C:5]4[CH:6]=[CH:7][C:2]([Cl:1])=[CH:3][C:4]=4[CH3:36])[CH2:9]/[C:10](=[N:19]\[OH:20])/[C:11]4[CH:16]=[CH:15][C:14](=[O:17])[N:13]([CH3:18])[CH:12]=4)=[CH:22][CH:23]=3)=[CH:28][CH:29]=2)=[O:35])=[N:43][N:42]=[N:41]1

Participants

4

Reactant 3

HCID 9886157Methanaminium, N-((dimethylamino)(3H-1,2,3-triazolo(4,5-b)pyridin-3-yloxy)methylene)-N-methyl-, hexafluorophosphate(1-) (1:1)HCID 56601932HCID 56601932, compoundHCID 178510704HCID 178510704, compound

Product 1

HCID 178426102HCID 178426102, compound

Procedure

In analogy to example 228, (E)-4′-(1-(4-chloro-2-methylphenyl)-3-(hydroxyimino)-3-(1-methyl-6-oxo-1,6-dihydropyridin-3-yl)propyl)biphenyl-4-carboxylic acid (example 227) was reacted with 5-aminomethyltetrazole in the presence of HATU to give the title compound as a light yellow foam, MS (ESI+): m/z=582.2 [M+H]+.

Sources & evidence

ORD record
ord-478cc7598afc428aa35c9fe256056bab
Source dataset
uspto-grants-2014_07
Patent number
US08765730B2

Reaction notes

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