HuagongsheHuagongshe Chemistry Print Report · For research reference only
Water → HCID 56602138, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Water | HCID 962 | — |
| Reactant | Sodium Carbonate | HCID 10340 | — |
| Reactant | 4-Carboxyphenylboronic Acid | HCID 312183 | — |
| Reactant | HCID 58043242 | HCID 58043242 | — |
| Catalyst | Bis(cyclopenta-1,4-dien-1-yl(diphenyl)phosphane);dichloropalladium;iron(2+) | HCID 44119782 | — |
| Solvent | 1,4-Dioxane | HCID 31275 | — |
| Product | HCID 56602138 | HCID 56602138 | — |
Reaction Steps
In analogy to example 166, step 1, 5-{3-(4-bromo-phenyl)-3-(4-chloro-2-fluoro-phenyl)-1-[(E)-hydroxyimino]-propyl}-1-methyl-1H-pyridin-2-one (example 237, step 5) was reacted with 4-carboxyphenylboronic acid in the presence of dichloro(1,1′-bis(diphenylphosphino)-ferrocene)palladium(II) dichloromethane adduct in a mixture of 1,4-dioxane, water and 2 M aqueous sodium carbonate solution to give the title compound containing 12% of the corresponding Z isomer as an off-white solid, MS (ESI+): m/z=502.8 [M−H]−.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08765730B2 |
| Source dataset | uspto-grants-2014_07 |
| ORD ID | ord-c777f363e691445cba7352e0a2858d80 |
| Source note | uspto-grants-2014_07 |