Glycine methyl ester hydrochloride → HCID 58043274, compound

HRID 1617785Notes

Reaction equation

HRID 1617785 reaction equation
[F:1][C:2]1[CH:7]=[CH:6][C:5]([CH:8]([C:21]2[CH:26]=[CH:25][C:24]([C:27]3[CH:32]=[CH:31][C:30]([C:33](O)=[O:34])=[CH:29][CH:28]=3)=[CH:23][CH:22]=2)[CH2:9]/[C:10](=[N:19]\[OH:20])/[C:11]2[CH:16]=[CH:15][C:14](=[O:17])[N:13]([CH3:18])[CH:12]=2)=[C:4]([CH3:36])[CH:3]=1.Cl.[CH3:38][O:39][C:40](=[O:43])[CH2:41][NH2:42]>>[CH3:38][O:39][C:40](=[O:43])[CH2:41][NH:42][C:33]([C:30]1[CH:31]=[CH:32][C:27]([C:24]2[CH:25]=[CH:26][C:21]([CH:8]([C:5]3[CH:6]=[CH:7][C:2]([F:1])=[CH:3][C:4]=3[CH3:36])[CH2:9]/[C:10](=[N:19]\[OH:20])/[C:11]3[CH:16]=[CH:15][C:14](=[O:17])[N:13]([CH3:18])[CH:12]=3)=[CH:22][CH:23]=2)=[CH:28][CH:29]=1)=[O:34]

Participants

3

Reactant 2

HCID 122755Glycine methyl ester hydrochlorideHCID 58043506HCID 58043506, compound

Product 1

HCID 58043274HCID 58043274, compound

Procedure

In analogy to example 228, from (E)-4′-(1-(4-fluoro-2-methylphenyl)-3-(hydroxyimino)-3-(1-methyl-6-oxo-1,6-dihydropyridin-3-yl)propyl)biphenyl-4-carboxylic acid (example 225) and glycine-methylester hydrochloride was prepared the title compound as a light brown foam, MS (ESI+): m/z=556.22 [M+H]+.

Sources & evidence

ORD record
ord-4628af0cdfcd4c41ba2981834b516c60
Source dataset
uspto-grants-2014_07
Patent number
US08765730B2

Reaction notes

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