4-(Tetramethyl-1,3,2-dioxaborolan-2-yl)aniline → HCID 58043284, compound

HRID 1617786Notes

Reaction equation

HRID 1617786 reaction equation
Br[C:2]1[CH:7]=[CH:6][C:5]([CH:8]([C:21]2[CH:26]=[CH:25][C:24]([F:27])=[CH:23][C:22]=2[CH3:28])[CH2:9]/[C:10](/[C:13]2[CH:14]=[CH:15][C:16](=[O:20])[N:17]([CH3:19])[CH:18]=2)=[N:11]\[OH:12])=[CH:4][CH:3]=1.[NH2:29][C:30]1[CH:35]=[CH:34][C:33](B2OC(C)(C)C(C)(C)O2)=[CH:32][CH:31]=1>>[NH2:29][C:30]1[CH:31]=[CH:32][C:33]([C:2]2[CH:3]=[CH:4][C:5]([CH:8]([C:21]3[CH:26]=[CH:25][C:24]([F:27])=[CH:23][C:22]=3[CH3:28])[CH2:9]/[C:10](/[C:13]3[CH:14]=[CH:15][C:16](=[O:20])[N:17]([CH3:19])[CH:18]=3)=[N:11]\[OH:12])=[CH:6][CH:7]=2)=[CH:34][CH:35]=1

Participants

3

Reactant 2

HCID 27346204-(Tetramethyl-1,3,2-dioxaborolan-2-yl)anilineHCID 58043184HCID 58043184, compound

Product 1

HCID 58043284HCID 58043284, compound

Procedure

In analogy to example 166, from (E)-5-(3-(4-bromophenyl)-3-(4-fluoro-2-methylphenyl)-1-(hydroxyimino)propyl)-1-methylpyridin-2(1H)-one (example 224) and 4-aminophenylboronic acid pinacol ester (CAS RN: [214360-73-3]) was prepared the title compound as a light brown foam, MS (ESI+): m/z=456.21 [M+H]+.

Sources & evidence

ORD record
ord-dcbde2acc7d34b4ea2e5300917baec55
Source dataset
uspto-grants-2014_07
Patent number
US08765730B2

Reaction notes

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