Hydroxyamine hydrochloride → diethyl 2-[4-[(1S,3E)-3-hydroxyimino-1-(2-methylphenyl)-3-(2-methyl-4-pyridinyl)propyl]phenyl]propanedioate

Participants

Reaction Steps

In analogy to example 1, step 2, from 2-{4-[(S)-3-(2-methyl-pyridin-4-yl)-3-oxo-1-o-tolyl-propyl]-phenyl}-malonic acid diethyl ester and hydroxylamine hydrochloride in the presence of sodium hydrogencarbonate was prepared the title compound as a mixture of E and Z isomers (2.7:1) as a white oil, MS (ESI+): m/z=489.3 ([M+H]+.

Provenance & Evidence