4-Carboxyphenylboronic Acid → HCID 66666716, compound

HRID 1617830Notes

Reaction equation

HRID 1617830 reaction equation
Br[C:2]1[CH:7]=[CH:6][C:5]([C@@H:8]([C:19]2[CH:24]=[CH:23][C:22]([Cl:25])=[CH:21][C:20]=2[CH3:26])[CH2:9][C:10]([C:12]2[CH:17]=[CH:16][N:15]=[C:14]([CH3:18])[CH:13]=2)=[O:11])=[CH:4][CH:3]=1.B([C:30]1[CH:38]=[CH:37][C:33]([C:34]([OH:36])=[O:35])=[CH:32][CH:31]=1)(O)O>>[Cl:25][C:22]1[CH:23]=[CH:24][C:19]([C@H:8]([C:5]2[CH:6]=[CH:7][C:2]([C:30]3[CH:38]=[CH:37][C:33]([C:34]([OH:36])=[O:35])=[CH:32][CH:31]=3)=[CH:3][CH:4]=2)[CH2:9][C:10]([C:12]2[CH:17]=[CH:16][N:15]=[C:14]([CH3:18])[CH:13]=2)=[O:11])=[C:20]([CH3:26])[CH:21]=1

Participants

3

Reactant 2

HCID 3121834-Carboxyphenylboronic AcidHCID 66667222HCID 66667222, compound

Product 1

HCID 66666716HCID 66666716, compound

Procedure

In analogy to example 74, step 6, from (S)-3-(4-bromo-phenyl)-3-(4-chloro-2-methyl-phenyl)-1-(2-methyl-pyridin-4-yl)-propan-1-one (example 282, step 1) and 4-boronobenzoic acid was prepared the title compound as an yellow foam.

Sources & evidence

ORD record
ord-845963ba43d141588836658068d859f1
Source dataset
uspto-grants-2014_07
Patent number
US08765730B2

Reaction notes

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