Hydroxyamine hydrochloride → HCID 58043432, compound

Participants

Reaction Steps

In analogy to example 151, step 3, 4-(3-(1-methyl-6-oxo-1,6-dihydropyridin-3-yl)-3-oxo-1-o-tolylpropyl)-N-(3,3,3-trifluoro-2-hydroxypropyl)benzamide was reacted with hydroxylamine hydrochloride in the presence of sodium hydrogencarbonate to give the title compound as an off-white solid containing <10% of the corresponding Z isomer, MS (ESI+): m/z=502.2 [M+H]+.

Provenance & Evidence