Hydroxyamine hydrochloride → HCID 58043441, compound

Participants

Reaction Steps

In analogy to example 151, step 3, 4-(1-(4-chloro-2-fluorophenyl)-3-(1-methyl-6-oxo-1,6-dihydropyridin-3-yl)-3-oxopropyl)-N—((R)-2,3-dihydroxypropyl)benzamide was reacted with hydroxylamine hydrochloride in the presence of sodium hydrogencarbonate to give the title compound as a colourless solid containing <10% of the corresponding Z isomer, MS (ESI+): m/z=502.1 [M+H]+.

Provenance & Evidence