Hydroxyamine hydrochloride → HCID 58043560, compound

Participants

Reaction Steps

In analogy to example 151, step 3, 5-(3-(4-chloro-2-fluorophenyl)-3-(4-(hydroxymethyl)-phenyl)propanoyl)-1-methylpyridin-2(1H)-one was reacted with hydroxylamine hydrochloride in the presence of sodium hydrogencarbonate to give the title compound as a colourless solid containing 15% of the corresponding Z isomer, MS (ESI+): m/z=415.2 [M+H]+.

Provenance & Evidence