HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-(Methylamino)ethanol → HCID 66668421, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-(Methylamino)ethanol | HCID 8016 | — |
| Reactant | Benzotriazol-1-yloxy-tris(dimethylamino)phosphonium hexafluorophosphate | HCID 151348 | — |
| Reactant | HCID 66669040 | HCID 66669040 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | HCID 66668421 | HCID 66668421 | — |
Reaction Steps
In analogy to example 207, step 2, 3-(1-(4-chloro-2-fluorophenyl)-3-(1-methyl-6-oxo-1,6-dihydropyridin-3-yl)-3-oxopropyl)benzoic acid (example 320, step 4) was coupled with 2-(methylamino)ethanol using benzotriazol-1-yloxytris(dimethylamino)phosphonium hexafluoro-phosphate in tetrahydrofuran to give the title compound as a colourless foam, MS (ESI+): m/z=471.4 [M+H]+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08765730B2 |
| Source dataset | uspto-grants-2014_07 |
| ORD ID | ord-d79045fc22dc493a91479b120b1e74ff |
| Source note | uspto-grants-2014_07 |