HuagongsheHuagongshe Chemistry Print Report · For research reference only
Cesium carbonate → 5-{3-(4-Chloro-2-methyl-phenyl)-3-[3-fluoro-4-(2-hydroxy-ethoxy)-phenyl]-propionyl}-1-methyl-1H-pyridin-2-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Cesium carbonate | HCID 10796 | — |
| Reactant | 2-Bromoethanol | HCID 10898 | — |
| Reactant | 5-[3-(4-Chloro-2-methyl-phenyl)-3-(3-fluoro-4-hydroxy-phenyl)-propionyl]-1-methyl-1H-pyridin-2-one | HCID 66669183 | — |
| Solvent | Dimethylacetamide | HCID 31374 | — |
| Product | 5-{3-(4-Chloro-2-methyl-phenyl)-3-[3-fluoro-4-(2-hydroxy-ethoxy)-phenyl]-propionyl}-1-methyl-1H-pyridin-2-one | HCID 67015595 | — |
Reaction Steps
In analogy to example 221, step 6, 5-[3-(4-chloro-2-methyl-phenyl)-3-(3-fluoro-4-hydroxy-phenyl)-propionyl]-1-methyl-1H-pyridin-2-one (example 324, step 1) was reacted with 2-bromoethanol in N,N-dimethylacetamide in the presence of cesium carbonate to give the title compound as a colourless foam, MS (ESI+): m/z=444.2 [M+H]+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08765730B2 |
| Source dataset | uspto-grants-2014_07 |
| ORD ID | ord-1bd6ea0254b14ebe9eead2af841daf9f |
| Source note | uspto-grants-2014_07 |