HuagongsheHuagongshe Chemistry Print Report · For research reference only
(4-Bromophenyl)boronic acid → 3-(4-Bromophenyl)-1-(6-methoxypyridin-3-yl)-3-(4-methylthiazol-5-yl)propan-1-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | (4-Bromophenyl)boronic acid | HCID 79599 | — |
| Reactant | Sodium Bicarbonate | HCID 516892 | — |
| Reactant | HCID 66667367 | HCID 66667367 | — |
| Catalyst | Rhodium, di-mu-chlorobis((1,2,5,6-eta)-1,5-cyclooctadiene)di- | HCID 6436379 | — |
| Solvent | Water | HCID 962 | — |
| Solvent | 1,4-Dioxane | HCID 31275 | — |
| Product | 3-(4-Bromophenyl)-1-(6-methoxypyridin-3-yl)-3-(4-methylthiazol-5-yl)propan-1-one | HCID 66666816 | — |
Reaction Steps
In analogy to example 203, step 1, (E)-1-(6-methoxypyridin-3-yl)-3-(4-methylthiazol-5-yl)prop-2-en-1-one was reacted with 4-bromophenylboronic acid in the presence of chloro(1,5-cyclooctadiene)rhodium(I) dimer and sodium hydrogencarbonate in 1,4-dioxane and water at 60° C. to give the title compound as a yellow solid, MS (ESI+): m/z=419.1 [M+H]+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08765730B2 |
| Source dataset | uspto-grants-2014_07 |
| ORD ID | ord-848b22e718ce44cabc902af2753febb1 |
| Source note | uspto-grants-2014_07 |