HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → 5-(3-(4-bromophenyl)-3-(4-methylthiazol-5-yl)propanoyl)pyridin-2(1H)-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | 3-(4-Bromophenyl)-1-(6-methoxypyridin-3-yl)-3-(4-methylthiazol-5-yl)propan-1-one | HCID 66666816 | — |
| Solvent | 1,4-Dioxane | HCID 31275 | — |
| Product | 5-(3-(4-bromophenyl)-3-(4-methylthiazol-5-yl)propanoyl)pyridin-2(1H)-one | HCID 66668555 | — |
Reaction Steps
In analogy to example 162, step 2, 3-(4-bromophenyl)-1-(6-methoxypyridin-3-yl)-3-(4-methylthiazol-5-yl)propan-1-one was reacted with concentrated aqueous HCl in 1,4-dioxane to give the title compound as an yellow solid, MS (ESI+): m/z=405.2 [M+H]+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08765730B2 |
| Source dataset | uspto-grants-2014_07 |
| ORD ID | ord-0b6384698c654928ad7bf29ab98e33f8 |
| Source note | uspto-grants-2014_07 |