HuagongsheHuagongshe Chemistry Print Report · For research reference only
Benzotriazol-1-yloxy-tris(dimethylamino)phosphonium hexafluorophosphate → HCID 67015730, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Benzotriazol-1-yloxy-tris(dimethylamino)phosphonium hexafluorophosphate | HCID 151348 | — |
| Reactant | (2R)-3-aminopropane-1,2-diol | HCID 6994409 | — |
| Reactant | HCID 66668648 | HCID 66668648 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | HCID 67015730 | HCID 67015730 | — |
Reaction Steps
In analogy to example 207, step 2, 4-(1-(4-chloro-2-methylphenyl)-3-(1-methyl-6-oxo-1,6-dihydropyridin-3-yl)-3-oxopropyl)benzoic acid (example 332, step 2) was coupled with (R)-3-aminopropane-1,2-diol using benzotriazol-1-yloxytris(dimethylamino)phosphonium hexafluorophosphate in tetrahydrofuran to give the title compound as an off-white solid, MS (ESI+): m/z=483.2 [M+H]+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08765730B2 |
| Source dataset | uspto-grants-2014_07 |
| ORD ID | ord-e8830f1892714a32806262801689362a |
| Source note | uspto-grants-2014_07 |