HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Bromoethanol → 5-(3-(4-Chloro-2-methylphenyl)-3-(4-(methylsulfonyl)phenyl)propanoyl)-1-(2-hydroxyethyl)pyridin-2(1H)-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Bromoethanol | HCID 10898 | — |
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | 5-(3-(4-chloro-2-methylphenyl)-3-(4-(methylsulfonyl)phenyl)propanoyl)pyridin-2(1H)-one | HCID 67015754 | — |
| Catalyst | Tetrabutylammonium Iodide | HCID 67553 | — |
| Product | 5-(3-(4-Chloro-2-methylphenyl)-3-(4-(methylsulfonyl)phenyl)propanoyl)-1-(2-hydroxyethyl)pyridin-2(1H)-one | HCID 66669044 | — |
Reaction Steps
In analogy to example 161, step 1, 5-(3-(4-chloro-2-methylphenyl)-3-(4-(methylsulfonyl)phenyl)propanoyl)pyridin-2(1H)-one (example 339, step 2) was reacted with 2-bromoethanol in the presence of potassium carbonate and a catalytic amount of tetrabutylammonium iodide to give the title compound as a light yellow solid, MS (ESI+): m/z=474.2 [M+H]+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08765730B2 |
| Source dataset | uspto-grants-2014_07 |
| ORD ID | ord-e197482bb1b6456ba76255a5117bec39 |
| Source note | uspto-grants-2014_07 |