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Pyridine → HCID 66668442、化合物
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Pyridine | HCID 1049 | — |
| 反応物 | (4-Chloro-3-(ethoxycarbonyl)phenyl)boronic acid | HCID 44119820 | — |
| 反応物 | 5-[3-(4-Chloro-2-methyl-phenyl)-3-(4-hydroxy-phenyl)-propionyl]-1-methyl-1H-pyridin-2-one | HCID 66669256 | — |
| 触媒 | Cupric acetate | HCID 8895 | — |
| 溶媒 | Dichloromethane | HCID 6344 | — |
| 生成物 | HCID 66668442 | HCID 66668442 | — |
反応手順
In analogy to example 222, step 1, 5-[3-(4-chloro-2-methyl-phenyl)-3-(4-hydroxy-phenyl)-propionyl]-1-methyl-1H-pyridin-2-one (example 346, step 1) was reacted with 4-chloro-3-ethoxycarbonylphenylboronic acid in dichloromethane in the presence of copper(II) acetate, pyridine and air to give the title compound as a colourless solid, MS (ESI+): m/z=564.2 [M+H]+.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08765730B2 |
| 出典データセット | uspto-grants-2014_07 |
| ORD ID | ord-038ad267e5b14c69824b710c97aca5cd |
| 出典メモ | uspto-grants-2014_07 |