Potassium Hydroxide → HCID 66668674, compound

HRID 1617945Notes

Reaction equation

HRID 1617945 reaction equation
[C:1]([C:4]1[CH:5]=[CH:6][C:7]([O:10][CH3:11])=[N:8][CH:9]=1)(=[O:3])[CH3:2].[F:12][C:13]1[CH:14]=[C:15]([CH:18]=[C:19]([F:21])[CH:20]=1)[CH:16]=O.[OH-].[K+]>>[F:12][C:13]1[CH:14]=[C:15](/[CH:16]=[CH:2]/[C:1]([C:4]2[CH:9]=[N:8][C:7]([O:10][CH3:11])=[CH:6][CH:5]=2)=[O:3])[CH:18]=[C:19]([F:21])[CH:20]=1

Participants

4

Reactant 3

HCID 14797Potassium HydroxideHCID 5881603,5-DifluorobenzaldehydeHCID 105348375-Acetyl-2-methoxypyridine

Product 1

HCID 66668674HCID 66668674, compound

Procedure

In analogy to example 170, step 1, 5-acetyl-2-methoxypyridine was reacted with 3,5-difluorobenzaldehyde in the presence of potassium hydroxide to give the title compound as a colourless solid. MS (ESI+): m/z=276.2 [M+H]+.

Sources & evidence

ORD record
ord-53b107b9b9c54e38b08e583fdaa169db
Source dataset
uspto-grants-2014_07
Patent number
US08765730B2

Reaction notes

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