Hydroxyamine hydrochloride → N-[4-[(3E)-1-(4-chloro-2-methylphenyl)-3-hydroxyimino-3-(1-methyl-6-oxo-3-pyridinyl)propyl]phenyl]methanesulfonamide

Participants

Reaction Steps

In analogy to example 151, step 3, N-{4-[1-(4-chloro-2-methyl-phenyl)-3-(1-methyl-6-oxo-1,6-dihydro-pyridin-3-yl)-3-oxo-propyl]-phenyl}-methanesulfonamide was reacted with hydroxylamine hydrochloride in the presence of sodium hydrogencarbonate to give the title compound containing 4% of the corresponding Z isomer as a colourless solid, MS (ESI+): m/z=474.2 [M+H]+.

Provenance & Evidence