2-Methylpyridine → HCID 66666307, compound

HRID 1617965Notes

Reaction equation

[Br:1][C:2]1[CH:7]=[CH:6][C:5]([C@H:8]([C:16]2[CH:21]=[CH:20][C:19]([Cl:22])=[CH:18][C:17]=2[CH3:23])[CH2:9][C:10](N(OC)C)=[O:11])=[CH:4][CH:3]=1.[CH3:24][C:25]1[CH:30]=[CH:29][CH:28]=[CH:27][N:26]=1>>[Br:1][C:2]1[CH:7]=[CH:6][C:5]([C@H:8]([C:16]2[CH:21]=[CH:20][C:19]([Cl:22])=[CH:18][C:17]=2[CH3:23])[CH2:9][C:10](=[O:11])[CH2:24][C:25]2[CH:30]=[CH:29][CH:28]=[CH:27][N:26]=2)=[CH:4][CH:3]=1

Participants

Reactant 2

HCID 79752-Methylpyridine

HCID 86661170HCID 86661170, compound

Product 1

HCID 66666307HCID 66666307, compound

Procedure

In analogy to example 261, step 1, from (R)-3-(4-bromo-phenyl)-3-(4-chloro-2-methyl-phenyl)-N-methoxy-N-methyl-propionamide and 2-methyl-pyridine was prepared the title compound as a yellow oil, MS (ESI+): m/z=430.0 ([M+H]+, 1Br).

Sources & evidence

ORD record: ord-287d31f19f574e04b494249e80b32568
Source dataset: uspto-grants-2014_07
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08765730B2

Reaction notes

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