Iodoethane → HCID 67015674, compound

Participants

Reaction Conditions

Reaction Steps

To a white suspension of (R)-3-(4-bromo-phenyl)-1-(2-methyl-pyridin-4-yl)-3-o-tolyl-propan-1-one (example 142, step 2, 200 mg) and potassium hydroxide (171 mg) in 1,4-dioxane (1 mL) and water (2 mL) under argon were added 2-di-tert-butylphosphino-2′,4′,6′-triisopropyl-biphenyl (17.2 mg) and tris(dibenzylideneacetone)dipalladium(0) (9.3 mg). The reaction mixture was heated to 100° C. and stirred for 3 hours. After cooling at room temperature, cetyl trimethyl-ammonium bromide (18.5 mg) and iodoethane (158 mg) were added. The reaction mixture was heated to 100° C. for 1 hour. A saturated aq. solution of ammonium chloride and ethyl acetate were added, the phases were separated and the inorganic one was extracted with ethyl acetate (2×). The combined organic layers were washed with brine, dried over sodium sulfate, filtered and concentrated in vacuo. The crude product was purified by flash chromatography on silica gel (0% to 50% ethyl acetate in heptane) to yield the title compound as a colourless liquid (90%), MS (ESI+): m/z=360.2 ([M+H]+).

Provenance & Evidence