Triethylamine → HCID 67015722, compound

Participants

Reaction Steps

A mixture of (R)-1-(4-(3-(2-methylpyridin-4-yl)-3-oxo-1-o-tolylpropyl)phenyl)-piperidine-4-carboxylic acid (100 mg, 226 μmol), triethylamine (229 mg, 2.26 mmol) and 0-(benzotriazol-1-yl)-N,N,N′,N′-tetramethyluronium tetrafluoroborate (218 mg, 678 μmol) in tetrahydrofuran (5 mL) was stirred at room temperature for 15 min, then treated with ammonium chloride (96.7 mg, 1.81 mmol), then after 20 h partitioned between sat. aq. ammonium chloride solution and ethyl acetate. The organic layer was washed with brine, dried over sodium sulfate, filtered, and evaporated to produce the crude title compound (131 mg), which was directly used in the next step. Yellow oil, MS (ESI+): m/z=442.4 ([M+H]+).

Provenance & Evidence